ea0070aep602 | Pituitary and Neuroendocrinology | ECE2020
Francesca Cassarino Maria
, Sesta Antonella
, Libera Laura
, Bardelli Donatella
, Losa Marco
, Lasio Giovanni
, Pecori Giraldi Francesca
Silibinin, a milk thistle extract with known hepatoprotective effects, has recently been shown to act upon tumoral corticotropes and revert the Cushingoid phenotype in an allograft mouse model (Riebold et al. 2015). Silbinin is known to inhibit HSP90 -a chaperone to the glucocorticoid receptor-thereby restoring sensitivity to glucocorticoid negative feedback in tumoral corticotropes. Aim of the present study was to assess the effect of silibinin on ACTH synthesis and ...